The Principles of Dietetics core concepts focus on understanding the scientific principles that govern the relationship between food, nutrients, and human health. It integrates foundational knowledge from biochemistry, physiology, and microbiology to explain how nutrients are digested, absorbed, metabolized, and utilized in the body. This review emphasizes evidence-based practice, nutrient composition analysis, food safety, and the impact of food systems on nutritional status. It prepares learners to apply scientific reasoning to dietary assessment, meal planning, and nutrition intervention across diverse populations.